Key result
Thirty minutes of standing significantly increased fibrinogen, factor V, and factor VIII activity by 12.0%, 13.0%, and 40.0% respectively (P<0.002 for all) in healthy volunteers.
Why the study?
Does orthostatic stress from standing induce hypercoagulability in healthy volunteers?
Population
18 healthy volunteers (9 females and 9 males), mean age 25+/-1.2 years, body mass index 21.7+/-0.5 kg/m2
Comparison
Still standing for 15, 30, and 60 minutes vs Rest supine
Design
Other
Follow-up
60 minutes
Authors
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May affect coagulation test timing after standing; leaves open contribution to VTE risk.
Observational (n=18)
Does orthostatic stress from standing induce hypercoagulability in healthy volunteers?
p-value: p=<0.002
Orthostatic stress from standing induces a procoagulant state, which may be relevant for interpreting coagulation tests and understanding the pathophysiology of venous thromboembolism.
Masoud et al. (2008) conducted an observational in Healthy (n=18). Orthostatic stress (standing) vs. Rest supine was evaluated on Coagulation system activation (fibrinogen, factor V, and factor VIII activity) (p=<0.002). Thirty minutes of standing significantly increased fibrinogen, factor V, and factor VIII activity by 12.0%, 13.0%, and 40.0% respectively (P<0.002 for all) in healthy volunteers.