Key result
ACTN3 577XX genotype linked to ~3x greater post-race serum myoglobin increases versus RX/RR carriers.
Why the study?
The influence of ACTN3 R577X gene polymorphism on muscle damage responses in ultra-endurance athletes was not well understood.
Does the ACTN3 577XX genotype increase muscle damage in ultra-runners after an adventure race compared to RX/RR genotypes?
Comparison
ACTN3 577XX genotype vs RX/RR genotypes
Design
Observational cohort study
Follow-up
Pre- to post-race
Authors
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May warrant genotype-informed monitoring in ultra-endurance athletes; hypothesis-generating for rhabdomyolysis risk stratification.
Observational (n=20)
No
Does the ACTN3 577XX genotype increase muscle damage in ultra-runners after an adventure race compared to RX/RR genotypes?
Standardized Mean Difference: 1.73
Absolute Event Rate: 5377% vs 1666%
p-value: p=0.005
Athletes with the ACTN3 577XX genotype experience significantly greater muscle damage after ultra-endurance races, suggesting higher susceptibility to rhabdomyolysis.
Belli et al. (2017) conducted an observational in Ultra-endurance sports / Adventure racing (n=20). ACTN3 577XX genotype vs. ACTN3 RX/RR genotypes was evaluated on Percentage change in serum myoglobin pre- to post-race (ES 1.73, p=0.005). Athletes with the ACTN3 577XX genotype experienced significantly greater percentage increases in serum myoglobin (5,377% vs 1,666%, p=0.005) after an adventure race compared to RX/RR carriers.
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