Key result
Repurposed CRISPR-Cas13 enables programmable regulation of translation in a cell-free expression system.
Demonstrates a novel framework for regulating translation using the CRISPR-Cas13 system in a cell-free expression model.
Hypothesis-generating for CRISPR-Cas13 translation control in cell-free models; in vivo validation required before broader application.
Development of a novel framework to regulate translation by repurposing the CRISPR-Cas13 immune system, exploiting a cell-free expression system for prototyping.
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Montagud‐Martínez et al. (2023) studied this question. The CRISPR-Cas13 immune system was repurposed to develop a novel framework for the programmable regulation of translation using a cell-free expression system.
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