Key result
TRPM3 ion channel provides major thermosensitive control over vagal signaling and synaptic transmission.
Why the study?
The role of thermosensitive TRP channels, specifically TRPM3, in vagal afferent signaling and synaptic transmission was less well understood.
TRPM3 may modulate temperature-sensitive vagal reflexes; leaves open its relevance to human cardiovascular autonomic control.
Vagal afferent signaling coordinates autonomic reflex function and informs associated behaviors. Thermosensitive transient receptor potential (TRP) channels detect temperature and nociceptive stimuli in somatosensory afferent neurons, however their role in vagal signaling remains less well understood. We report that the TRPM3 ion channel provides a major thermosensitive point of control over vagal signaling and synaptic transmission. We conclude that TRPM3 translates physiological changes in temperature to neurophysiological outputs and can serve as a cellular integrator in vagal afferent signaling.
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Ragozzino et al. (2020) studied this question. TRPM3 ion channel was evaluated on vagal signaling and synaptic transmission. The TRPM3 ion channel provides a major thermosensitive point of control over vagal signaling and synaptic transmission.
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