An original procedure for efficient synthesis of a functionalized salen·copper complex is reported. The mode of binding to DNA of the salen·Cu II complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen·Cu II complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.
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Routier et al. (1996) studied this question.
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