Key result
P19 interacts with BAM1 and BAM2 to suppress RNA silencing movement independently of sRNA binding.
Why the study?
The molecular mechanisms by which the viral silencing suppressor P19 interacts with host proteins to suppress RNA silencing were not fully understood.
The study identifies BAM1/2 as targets for the viral silencing suppressor P19, suggesting potential candidates for anti-viral breeding in plants.
May enable antiviral crop engineering; leaves open conservation across viruses and hosts.
Taken together, our results shed new light onto the molecular mechanisms underpinning the role of P19 in silencing suppression, and uncover BAM1/2 as proteins convergently targeted by independently evolved plant viruses, making them emerge as potentially interesting candidates for anti-viral breeding and editing strategies to be explored in the future.
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Gómez et al. (2020) studied this question. The viral silencing suppressor P19 interacts with receptor-like kinases BAM1 and BAM2 to suppress cell-to-cell movement of RNA silencing independently of its ability to bind sRNA.
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