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June 1, 2007Cancer ResearchOpen Access

Mel-18 Acts as a Tumor Suppressor by Repressing Bmi-1 Expression and Down-regulating Akt Activity in Breast Cancer Cells

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Authors

WGWeijian GuoShanghai Medical College of Fudan UniversityMZMu‐Sheng ZengSun Yat-sen UniversityAYAjay K. YadavUniversity of Oslo

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Guo et al. (2007) studied this question.

synapsesocial.com/papers/6ab0c83ff277a8cda32dac34https://doi.org/10.1158/0008-5472.can-06-4368
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mel-18, a Polycomb Group Protein, Regulates Cell Proliferation and Senescence via Transcriptional Repression of Bmi-1 and c-Myc Oncoproteins2006 · 143 citations
  2. 2Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.1990 · 304 citations
  3. 3Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression2003 · 889 citations
  4. 4Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival2006 · 173 citations
  5. 5Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer2004 · 185 citations