Treatment of triene sulfoxides with t-BuLi and methanol-O-d1 in D2O-wet ether leads to trienes with practical levels (96%) of deuterium incorporation. Alternatively, successive treatment of triene sulfoxides dwith CH3Li and then t-BuLi followed by methanol-O-d1 quench affords similar levels of label incorporation.
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Park et al. (1991) studied this question.
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