Population
C2C12 cells, primary human myoblasts, and mice with conditional deletion of p110β in skeletal muscle
Comparison
Pharmacological inhibition, conditional… vs Control littermates (for mice) or control cells
Design
Preclinical
Key result
Conditional deletion of p110β in skeletal muscle impaired whole-body glucose tolerance in old mice without affecting long-term muscle size or strength, while its inhibition delayed myogenesis.
Authors
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May caution against p110β inhibition in aging; hypothesis-generating for its metabolic role, requiring human validation.
PI3K p110β plays a role in skeletal myogenesis, and its long-term reduction in skeletal muscle impairs whole-body glucose tolerance in mice.
Matheny et al. (2015) studied Skeletal myogenesis and metabolism. p110β deletion or inhibition vs. Control littermates or uninhibited cells was evaluated on Myoblast differentiation, muscle mass, strength, and glucose tolerance. Conditional deletion of p110β in skeletal muscle impaired whole-body glucose tolerance in old mice without affecting long-term muscle size or strength, while its inhibition delayed myogenesis.