Key result
Pathological adipose tissue alterations are linked to obesity-related cancers via inflammation and insulin resistance.
Why the study?
The mechanisms linking dysfunctional adipose tissue and obesity-related cancer development and progression remain obscure despite recognized associations.
This review highlights how pathological alterations in hypertrophic adipose tissue, such as inflammation and metabolic dysregulation, may contribute to the development of obesity-related cancers.
May link hypertrophic adipose tissue to obesity-related cancer risk; hypothesis-generating for mechanistic and interventional studies.
The relation between cancer and metabolic disorders was recognized several decades ago, but the underlying mechanisms involved in cancer development and progression remain obscure. In the last years, many groups have been studying systemic adipose tissue markers in cancer patients. However, few consistent results were obtained. On the other hand, several studies revealed many aspects of adipose tissue physiology in obesity. Nowadays, it is recognized that excessive lipid uptake in adipocytes leads to hypertrophy and consequently to metabolic dysregulation, hypoxia, inflammation, impaired adipocytokine expression and angiogenesis, insulin resistance and macrophage recruitment. In obese patients, tumours commonly colocalize with excessive adipose tissue accumulation, and most of the features of hypertrophic adipose tissue are observed in cancer patients, namely breast and colon. This review aimed to summarize pathological adipose tissue alterations that may contribute to cancer aetiology and development.
No takes yet. Share an insight, caveat, or question.
Matafome et al. (2013) conducted a review in Obesity-related cancers. Dysfunctional adipose tissue was evaluated. Pathological adipose tissue alterations, including hypertrophy, hypoxia, inflammation, and insulin resistance, may contribute to the etiology and development of obesity-related cancers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: