Key result
Dysfunctional adipose tissue and obesity contribute to an aggressive tumor phenotype by altering the tumor microenvironment through hypoxia, tumor-associated adipocytes, and the CXCR4 homing protein.
Dysfunctional adipose tissue in obese patients significantly alters the tumor microenvironment, promoting aggressive cancer phenotypes through mechanisms like hypoxia and altered adipokine signaling.
Adipose dysfunction may worsen cancer outcomes in obesity; leaves open whether targeting it improves cardio-oncology prognosis.
Summary. The authors have reviewed, analyzed, and summarized data from scientific literature concerning the issue of the influence of dysfunctional adipose tissue on microenvironment and course of oncological disease in overweight patients. We presented an epidemiological data about connection between obesity and survival rates of cancer ill patients. Phenomena of ’obesity paradox’ and basic characteristics of hypertrophic fatty tissue were described in this paper. We inspected the role of intratumoral hypoxia, tumor-associated adipocytes, tumorinfiltrating lymphocytes, and homing protein CXC4R in the formation of aggressive phenotype of a malignant tumor during obesity.
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Bubnovskaya et al. (2023) conducted a review in Cancer and Obesity. Dysfunctional adipose tissue and obesity was evaluated. Dysfunctional adipose tissue and obesity contribute to an aggressive tumor phenotype by altering the tumor microenvironment through hypoxia, tumor-associated adipocytes, and the CXCR4 homing protein.
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