Key result
Obesity favors the proliferation and aggressiveness of melanoma cells through a direct dialog mediated by soluble factors and exosomes, and through remodeling of the tumor microenvironment.
Why the study?
Does obesity impact melanoma incidence and progression?
Does obesity impact melanoma incidence and progression?
Obesity and adipose tissue contribute to melanoma progression and aggressiveness, suggesting a need for personalized therapeutic options for obese melanoma patients.
Suggests obesity as modifiable factor in melanoma progression; leaves open whether interventions improve outcomes.
Over the last decade, it has become increasingly clear that adipose tissue, and particularly adipocytes, contributes to tumor progression. Obesity, an ever-increasing worldwide phenomenon, exacerbates this effect. The influence of obesity on melanoma remains poorly studied, although recent data do underline an association between the two diseases in both humans and murine models. Herein, we review the impact of obesity on melanoma incidence and progression and discuss the underlying mechanisms known to be involved. Adipose tissue favors the proliferation and aggressiveness of melanoma cells through a direct dialog, mediated by soluble factors and by exosomes, and through remodeling of the tumor microenvironment. This knowledge could, in the future, help to design new personalized therapeutic options for obese melanoma patients.
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Clement et al. (2017) conducted a review in Obesity and melanoma. Obesity was evaluated. Obesity favors the proliferation and aggressiveness of melanoma cells through a direct dialog mediated by soluble factors and exosomes, and through remodeling of the tumor microenvironment.
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