Key result
Cold facial immersion fails to reduce physiological CO2 sensitivity but is linked to lower self-reported anxiety.
Why the study?
Individuals with panic disorder exhibit heightened CO2 sensitivity, and the potential of the diving response to modulate this sensitivity and reduce panic symptoms was unexplored.
Does cold facial immersion reduce CO2 sensitivity and panic-related symptoms in individuals with panic disorder?
Does cold facial immersion reduce CO2 sensitivity and panic-related symptoms in individuals with panic disorder?
Cold facial immersion demonstrated anxiolytic effects in individuals with panic disorder, reducing self-reported anxiety and panic symptoms.
Answers are grounded in this paper and cite their sources.
May reduce subjective panic symptoms without affecting CO2 sensitivity; leaves open therapeutic utility pending controlled trials.
Introduction Breath-hold divers are known for their exceptional breathing control and reduced carbon dioxide (CO2) sensitivity due to training adaptations. In contrast, individuals with panic disorder (PD) often exhibit heightened CO2 sensitivity. This study aimed to explore the potential clinical applications of the diving response (DR), particularly cold facial immersion (CFI), in mitigating panic-related symptoms and cognitions by modulating CO2 sensitivity. Methods This study investigated the effects of the CFI task on individuals with PD and a comparison group. Changes in heart rate, respiration rate, and psychological measures were assessed before and after a CO2 challenge to determine whether the CFI task could reduce CO2 sensitivity and panic-related symptoms. Results The results did not support the efficacy of the CFI task in reducing physiological markers of CO2 sensitivity—specifically, heart rate and respiration rate—following the CO2 challenge in either the clinical or comparison group, potentially due to the small sample size. However, significant reductions in both physiological and cognitive symptoms of panic were observed in the clinical group following the CFI task. Discussion As hypothesized, the CFI task demonstrated anxiolytic effects in individuals with PD by reducing self-reported anxiety and panic symptoms. These findings highlight the potential of the CFI task for clinical application in the treatment of panic disorder, warranting further research with larger samples.
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Peter Kyriakoulis (2025) studied Panic disorder (n=30). Cold facial immersion (CFI) vs. CO2 challenge without CFI was evaluated on Changes in physiological markers of CO2 sensitivity (heart rate and respiration rate) following the CO2 challenge (p=0.38). Cold facial immersion did not significantly reduce physiological markers of CO2 sensitivity following a CO2 challenge, but it significantly reduced self-reported anxiety and panic symptoms in individuals with panic disorder.
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