SummaryA single injection of as little as 0.0001 μg of lipopolysaccharide from Escherichia coli produced a hypoferremia in the rat. The maximum decrease in plasma iron occurred 8 to 16 hours after injection. A tolerance to this endotoxin was produced by repeated daily injections. An endogenous, heat labile factor, which would decrease plasma iron, was formed in the plasma, 2 hours after injection of endotoxin.
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Kampschmidt et al. (1962) studied this question.