Key result
Type 2 diabetes in hypertensive patients is linked to elevated blood NGAL and cystatin C.
Why the study?
The diagnostic significance of neutrophil gelatinase-associated lipocalin and cystatin C and their correlation with intrarenal hemodynamic parameters in patients with arterial hypertension and type 2 diabetes mellitus was unclear.
Are blood NGAL, cystatin C, and intrarenal hemodynamic parameters useful for early detection of diabetic nephropathy in patients with arterial hypertension and type 2 diabetes mellitus?
Observational
Are blood NGAL, cystatin C, and intrarenal hemodynamic parameters useful for early detection of diabetic nephropathy in patients with arterial hypertension and type 2 diabetes mellitus?
Blood NGAL, cystatin C, and renal artery duplex scanning parameters may serve as early diagnostic markers for diabetic nephropathy in patients with hypertension and type 2 diabetes.
May support early renal monitoring in hypertensive diabetes; hypothesis-generating and requires prospective validation before clinical adoption.
The purpose of the study was to clarify the diagnostic significance of neutrophil gelatinase-associated lipocalin and cystatin C in the blood of patients with arterial hypertension and type 2 diabetes mellitus and their correlation with intrarenal hemodynamic parameters. It was installed that in comparison with persons without diabetes in patients with arterial hypertension and type 2 diabetes mellitus at the stage of preclinical kidney damage found a more significant increase in neutrophil gelatinase-associated lipocalin and cystatin C in the blood. This allows us to consider these indicators as diagnostic manifestations of early detection of diabetic nephropathy. It was determined that a significant decrease in the final diastolic arterial blood flow velocities and a significant increase in the resistance index are diagnostic markers of morpho-functional changes in the kidneys during duplex scanning of the renal arteries in patients with arterial hypertension and type 2 diabetes mellitus.
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Бiловол et al. (2022) conducted an observational in Arterial hypertension and type 2 diabetes mellitus. Type 2 diabetes mellitus vs. Persons without diabetes was evaluated on Blood levels of neutrophil gelatinase-associated lipocalin and cystatin C. Patients with arterial hypertension and type 2 diabetes mellitus had a significant increase in blood neutrophil gelatinase-associated lipocalin and cystatin C compared to those without diabetes.
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