Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?2006 · 172 citations
2. 2Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib:  New Pharmacological Opportunities Due to Related Binding Site Recognition2003 · 456 citations
3. 3Celecoxib Induces Apoptosis by Inhibiting 3-Phosphoinositide-dependent Protein Kinase-1 Activity in the Human Colon Cancer HT-29 Cell Line2002 · 303 citations
4. 4Cyclooxygenase-2 (COX-2)–Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors2006 · 475 citations
5. 53-Phosphoinositide-Dependent Protein Kinase-1/Akt Signaling Represents a Major Cyclooxygenase-2-Independent Target for Celecoxib in Prostate Cancer Cells2004 · 249 citations