The Structure of the Neuropeptide Bradykinin Bound to the Human G‐Protein Coupled Receptor Bradykinin B2 as Determined by Solid‐State NMR Spectroscopy

Triggering the signal: The backbone structure of the nine amino acid neuropeptide bradykinin (see picture) bound to the human G-protein coupled bradykinin subtype 2 receptor has been determined by solid-state NMR spectroscopy. Torsion-angle constraints based on 13C chemical shifts were used for structure calculation, which revealed an elongated conformation with an α-helical turn at the N terminus and a β turn at the C terminus.