Key result
Vitamin D deficiency linked to late diabetic peripheral neuropathy in females with type 2 diabetes.
Why the study?
The association between vitamin D deficiency, BMI, atherogenic index, HbA1c, and diabetic peripheral neuropathy in type II diabetic females was unclear.
Are Vitamin D deficiency, BMI, atherogenic index, and HbA1c associated with the prevalence and severity of diabetic peripheral neuropathy in Type II diabetic females?
Cross-Sectional (n=95)
No
Are Vitamin D deficiency, BMI, atherogenic index, and HbA1c associated with the prevalence and severity of diabetic peripheral neuropathy in Type II diabetic females?
Absolute Event Rate: 15% vs 22%
p-value: p=0.002
Vitamin D deficiency, hyperglycemia, obesity, and dyslipidemia are independent risk factors for diabetic peripheral neuropathy in females with Type 2 diabetes.
Vitamin D deficiency may mark DPN progression in diabetic women; leaves open whether supplementation modifies neuropathy risk or severity.
Objectives: To explore the possible association between vitamin D deficiency, body mass index (BMI), atherogenic index (AI), and glycosylated heamoglobin (HbA1c) with diabetic peripheral neuropathy(DPN).Also, with the electrophysiological measures of nerve impairment and sensory loss Methods: This study was conducted at the Clinical Physiology Laboratory and Diabetes Research Center of King Abdul Aziz University Hospital (Riyadh, Saudi Arabia) , between January 2018 to May 2019 ,involved 15 subjects with controlled diabetes ,30 diabetic patients with possible DPN and 50 diabetic patient with DPN.Electrophysiological nerve conduction studies and serum 25(OH)D ,lipid profile and HbA1c were measured.Results: the present study reveals a significant deficiency of Vit D in group III ( late DPN) compared to early DPN (group II) and its negative correlation with DPN electrophysiological measures of median, ulnar, peroneal and tibial nerves motor potential latency , and with median and sural nerves sensory potential latency, also its positive correlation with sural nerve sensory amplitude, also with sensory and motor nerves conduction velocity.The current study showed that subjects who had late DPN had a longer duration of diabetes, and higher mean hemoglobin A1c, atherogenic index, BMI than those who have possible early neuropathy.Deficiency of Vit D, high atherogenic index, BMI and HbA1c are predictors and risk factors for DPN.Conclusion: Vit D deficiency, hyperglycemia, Hb A1c, obesity and dyslipidemia are independent risk factors of DPN as a microvascular complication in T2DM patients.Sensory large myelinated nerve integrity also correlated with BMI and atherogenic index.
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Faten A Zakareia (2019) conducted a cross-sectional in Diabetic Peripheral Polyneuropathy in Type 2 Diabetes (n=95). Vitamin D deficiency vs. Normal Vitamin D status was evaluated on Serum 25-OH-Vitamin D level (ng/ml) (p=0.002). Vitamin D deficiency was significantly associated with late diabetic peripheral neuropathy in females with type 2 diabetes (mean serum level 15 ng/ml vs 22 ng/ml in early neuropathy, p=0.002).
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