Key result
NAFLD links to lower LV GLS versus healthy controls, related to insulin resistance.
Why the study?
The evaluation of left ventricular systolic function using 2D speckle-tracking echocardiography in patients with NAFLD and its subgroups was needed to understand myocardial dysfunction.
Is nonalcoholic fatty liver disease associated with impaired left ventricular systolic function as measured by 2D-STE?
Population
55 patients with biopsy-proven NAFLD and 21 healthy controls
Comparison
NAFLD patients vs healthy controls
Design
Cross-sectional study
Authors
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Subclinical LV dysfunction in NAFLD may reflect insulin resistance rather than liver disease; leaves open 2D-STE utility beyond metabolic assessment.
Cross-Sectional (n=76)
Is nonalcoholic fatty liver disease associated with impaired left ventricular systolic function as measured by 2D-STE?
Subclinical myocardial dysfunction in NAFLD patients appears to be related to associated metabolic factors like insulin resistance rather than the liver disease itself, and 2D-STE cannot differentiate NAFLD histological subgroups.
Karabay et al. (2013) conducted a cross-sectional in Nonalcoholic fatty liver disease (n=76). Nonalcoholic fatty liver disease vs. Healthy controls was evaluated on Left ventricular global longitudinal strain (G-LS) and strain rate in systole (G-SRsys). Nonalcoholic fatty liver disease was associated with significantly lower left ventricular global longitudinal strain compared to healthy controls, related to the presence of insulin resistance.
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