Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
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Beckloff et al. (2008) studied this question.
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