Key result
Fasting index yields a ~0.66 correlation with insulin sensitivity, matching ISI composite in type 2 diabetics.
Why the study?
A simple and useful tool for estimating insulin resistance in nonobese Japanese type 2 diabetic patients was needed as alternatives to oral glucose tolerance test-based indices.
Does the 1/(log glucose x log insulin) index accurately estimate insulin resistance compared to established indices in nonobese Japanese type 2 diabetic patients?
Observational
Does the 1/(log glucose x log insulin) index accurately estimate insulin resistance compared to established indices in nonobese Japanese type 2 diabetic patients?
Answers are grounded in this paper and cite their sources.
The 1/(log glucose x log insulin) index offers a simple, fasting-state alternative to oral glucose tolerance tests for estimating insulin resistance in nonobese Japanese type 2 diabetic patients.
correlated with the minimal modelderived insulin sensitivity in nonobese Japanese type 2 diabetic patients.Furthermore, the correlation coefficient between MINMOD-SI and 1/(log glucose ϫ log insulin) (r ϭ 0.658) was similar to that between MINMOD-SI and the insulin sensitivity index (ISI, composite) (r ϭ 0.677) proposed by Matsuda and De-Fronzo (3,10).Whereas the ISI (composite) requires an oral glucose tolerance test, 1/(log glucose ϫ log insulin) can be calculated from the fasting state.Thus, 1/(log glucose ϫ log insulin) is considered to be a simple and useful tool for the estimation of insulin resistance in nonobese Japanese type 2 diabetic patients.
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Várkonyi et al. (2002) conducted an observational in Type 2 diabetes. 1/(log glucose x log insulin) index vs. Insulin sensitivity index (ISI, composite) was evaluated on Correlation with minimal model-derived insulin sensitivity (MINMOD-SI) (r = 0.658). The fasting index 1/(log glucose x log insulin) correlated with minimal model-derived insulin sensitivity (r=0.658) similarly to the ISI composite (r=0.677) in nonobese Japanese type 2 diabetics.
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