What question did this study set out to answer?

July 1, 2000The Journal of Clinical Endocrinology & Metabolism

Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans

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Authors

AKAlexis KatzTulane University

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Implication

Validation study reveals that the Quantitative Insulin Sensitivity Check Index strongly correlates with gold-standard clamp measurements, highlighting a simple fasting test for clinical research.

Key Points

To develop and validate a simple, accurate method for assessing insulin sensitivity in humans using routine fasting blood samples.
Evaluated 28 non-obese, 13 obese, and 15 type 2 diabetic subjects using hyperinsulinemic isoglycemic glucose clamps and insulin-modified frequently sampled intravenous glucose tolerance tests.
Derived the Quantitative Insulin Sensitivity Check Index (QUICKI = 1/[log(fasting insulin) + log(fasting glucose)]) from steady-state fasting values.
Tested external validity in an independent cohort of 21 obese and 14 non-obese individuals from another institution.
QUICKI demonstrated a significantly higher correlation with glucose clamp-derived insulin sensitivity (SIClamp, r = 0.78) than minimal model analysis did (SIMM, r = 0.57).
External validation in the independent cohort of 35 subjects confirmed a comparable strong correlation between QUICKI and clamp measurements.

Cite This Study

Alexis Katz (2000) studied this question.

synapsesocial.com/papers/6a001629ef8139f8ff7780fb https://doi.org/10.1210/jc.85.7.2402

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Implication

Validation study reveals that the Quantitative Insulin Sensitivity Check Index strongly correlates with gold-standard clamp measurements, highlighting a simple fasting test for clinical research.

Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

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