Key result
A high-dose intravenous glucose tolerance test with minimal model analysis yielded insulin sensitivity indices that correlated strongly (r=0.72-0.92, P<0.01) with euglycaemic clamp measures.
Why the study?
Does the minimal model using high-dose intravenous glucose tolerance test provide a valid measure of insulin sensitivity compared to the euglycaemic clamp in healthy subjects and heart failure patients?
Population
15 subjects
Comparison
High-dose, unmodified intravenous glucose… vs Euglycaemic clamp (reference technique)
Design
Cross-sectional
Authors
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May support high-dose IVGTT minimal model as economical alternative; leaves open prospective validation before clinical adoption.
Observational (n=15)
Does the minimal model using high-dose intravenous glucose tolerance test provide a valid measure of insulin sensitivity compared to the euglycaemic clamp in healthy subjects and heart failure patients?
Effect estimate: Correlation coefficients 0.72-0.92
p-value: p=<0.01 to <0.001
The high-dose intravenous glucose tolerance test with minimal model analysis provides a valid and economical measure of insulin sensitivity compared to the euglycaemic clamp.
Swan et al. (1994) conducted an observational in Health and severe heart failure (n=15). High-dose unmodified intravenous glucose tolerance test with minimal model analysis vs. Euglycaemic clamp was evaluated on Correlation of insulin sensitivity index between minimal model and clamp-derived measures (Correlation coefficients 0.72-0.92, p=<0.01 to <0.001). A high-dose intravenous glucose tolerance test with minimal model analysis yielded insulin sensitivity indices that correlated strongly (r=0.72-0.92, P<0.01) with euglycaemic clamp measures.
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