Key result
Fatal post-MI myocardial rupture is linked to a 0% incidence of prior infarction.
Why the study?
The clinical characteristics distinguishing patients with myocardial rupture after acute myocardial infarction compared to those without rupture and survivors were not well defined.
Comparison
Patients who died from myocardial rupture vs those who died without rupture vs survivors
Design
Observational cohort study
Follow-up
Hospitalization
Authors
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Absence of prior infarction may flag higher rupture risk after acute MI; hypothesis-generating for protective preconditioning, needs prospective validation.
Observational (n=1,136)
Myocardial rupture in acute myocardial infarction is strongly associated with a lack of previous myocardial infarction or angina, suggesting that prior ischemic events may confer a protective effect against rupture.
Herlitz et al. (1988) conducted an observational in acute myocardial infarction (n=1,136). Myocardial rupture vs. Death without rupture or survival was evaluated on Previous myocardial infarction, previous angina pectoris, and clinical course. Patients dying from myocardial rupture after acute myocardial infarction had a 0% incidence of previous infarction compared to 25-31% in those who died without rupture and 20-34% in survivors.
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