Key result
Steatohepatitis linked to ~2-fold higher osteoporosis prevalence versus liver steatosis.
Why the study?
Bone disorders are often detected in patients with non-alcoholic fatty liver disease, but the effect of NAFLD on bone tissue condition and its relation to liver pathology severity requires clarification.
Is non-alcoholic fatty liver disease associated with decreased bone mineral density and osteoporosis in women?
Cross-Sectional (n=98)
Is non-alcoholic fatty liver disease associated with decreased bone mineral density and osteoporosis in women?
NAFLD at the stage of steatohepatitis is associated with a significantly increased risk of osteoporosis and decreased bone mineral density in women.
SUMMARY Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Its comorbid course with various diseases is noted. It has been established that bone disorders are often detected in NAFLD. The purpose of the study. To clarify the effect of NAFLD on the condition of bone tissue, the dependence of changes in BMD and the severity of the pathological process in the liver. Materials and methods. 98 women were examined, with an average age of 53.3±6.24 years. All individuals underwent a clinical examination, body mass index was calculated, ultrasound examination (ultrasound) of the abdominal cavity, two-energy X-ray absorptimetry of the lumbar spine (LS) and femoral neck (FN) with clarification of the value of the T-criterion, esophagogastroduodenoscopy, biochemical blood analysis were performed. All patients were divided into 3 groups: the first group consisted of 47 people with liver steatosis, the second group included 25 people with steatohepatitis. The control group included 26 women with the results of biochemical blood parameters within the reference values and unchanged liver ultrasound data. Results. The analysis of clinical symptoms showed the presence of asthenic syndrome/chronic fatigue in all patients with NAFLD, while the severity of symptoms increased with steatohepatitis. According to densitometry, the average values of the T-criterion in both SB and POP did not significantly differ in patients with liver steatosis and the control group. In patients with steatohepatitis, there was a significant decrease in the T-criterion in both study areas. The prevalence of osteoporosis (OP) and osteopenia in the first and control groups did not differ statistically. In steatohepatitis, OP was detected twice as often as in liver steatosis. Conclusions. The presented data indicate that asthenic syndrome dominates the clinical picture of NAFLD. The results of the study confirm the comorbid course of NAFLD at the stage of steatohepatitis and OP.
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Л. А. Фомина (2025) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=98). Non-alcoholic fatty liver disease (steatohepatitis and liver steatosis) vs. Healthy controls was evaluated on Bone mineral density (T-criterion) and prevalence of osteoporosis. Steatohepatitis was associated with a significant decrease in bone mineral density T-scores and a twofold higher prevalence of osteoporosis compared to liver steatosis.
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