Key result
Higher daily physical activity linked to better brachial artery FMD in patients with PAD.
Why the study?
The association between higher levels of physical activity during daily life and brachial artery flow-mediated dilation in individuals with peripheral arterial disease was unclear.
Does higher physical activity in daily life improve brachial artery flow-mediated dilation in patients with peripheral arterial disease?
Cross-Sectional (n=111)
Does higher physical activity in daily life improve brachial artery flow-mediated dilation in patients with peripheral arterial disease?
Higher levels of daily physical activity are independently associated with better endothelial function, as measured by brachial artery flow-mediated dilation, in patients with peripheral arterial disease.
We determined whether higher levels of physical activity in daily life are associated with better brachial artery flow-mediated dilation (FMD) among individuals with lower extremity peripheral arterial disease (PAD). Participants were 111 men and women with PAD (ankle–brachial index (ABI) ≤ 0.95) who completed baseline testing in the Study to Improve Leg Circulation (SILC). We evaluated FMD of the brachial artery at baseline and at 60 seconds following 4 minutes of suprasystolic blood pressure cuff inflation. Physical activity was measured continuously over 7 days using a vertical accelerometer (Caltrac) and a pedometer (Digiwalker). Adjusting for age, sex, race, ABI, cardiovascular risk factors and other potential confounders, higher levels of physical activity were associated with a greater percent change in brachial artery FMD at 60 seconds post cuff deflation for both Caltrac (1st tertile of activity +4.81% change; 2nd tertile +4.60% change; 3rd tertile +7.23% change; p-trend = 0.018) and the Digiwalker (1st tertile of activity +3.76% change; 2nd tertile +6.25% change; 3rd tertile +7.25% change; p-trend = 0.001). Similar findings were observed for absolute change in brachial artery FMD 60 seconds after cuff deflation. In conclusion, higher levels of physical activity during daily life are associated significantly and independently with better brachial artery FMD among individuals with PAD, even after adjusting for confounders. ClinicalTrials.gov Identifier: NCT00106327.
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Payvandi et al. (2009) conducted a cross-sectional in lower extremity peripheral arterial disease (PAD) (n=111). Higher levels of physical activity vs. Lower levels of physical activity (1st tertile) was evaluated on percent change in brachial artery FMD at 60 seconds post cuff deflation (p=0.018). Higher levels of daily physical activity were independently associated with better brachial artery flow-mediated dilation among individuals with peripheral arterial disease (p-trend=0.018).
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