Key result
Brachial flow-mediated dilation predicted incident cardiovascular events (HR 0.91 per SD; 95% CI 0.83-0.99; P=0.02) but added only ~1% to the prognostic accuracy of traditional risk factors.
Why the study?
Does brachial flow-mediated dilation predict incident cardiovascular events in older adults?
Cohort (n=2,792)
Yes
Does brachial flow-mediated dilation predict incident cardiovascular events in older adults?
Effect estimate: HR 0.91 (95% CI 0.83 to 0.99)
Absolute Event Rate: 78.3% vs 73.6%
p-value: p=0.02
While brachial flow-mediated dilation predicts future cardiovascular events in older adults, it adds minimal prognostic value beyond traditional cardiovascular risk factors.
No takes yet. Share an insight, caveat, or question.
Adds minimal prognostic value beyond traditional factors; hypothesis-generating and should not yet change practice.
Yeboah et al. (2007) conducted a cohort in Incident cardiovascular events (n=2,792). Brachial flow-mediated dilation (FMD) vs. FMD less than or equal to sex-specific medians was evaluated on Incident cardiovascular events (HR 0.91, 95% CI 0.83 to 0.99, p=0.02). Brachial flow-mediated dilation predicted incident cardiovascular events (HR 0.91 per SD; 95% CI 0.83-0.99; P=0.02) but added only ~1% to the prognostic accuracy of traditional risk factors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: