Key result
Brachial flow-mediated dilation predicted incident cardiovascular events (HR 0.91 per SD; 95% CI 0.83-0.99; P=0.02) but added only ~1% to the prognostic accuracy of traditional risk factors.
Why the study?
Does brachial flow-mediated dilation predict incident cardiovascular events in older adults?
Population
2,792 older adults aged 72 to 98 years from the Cardiovascular Health Study, recruited at 4 clinic sites in…
Comparison
Brachial flow-mediated dilation (FMD) measurement vs FMD greater than sex-specific medians versus FMD…
Design
Cohort
Follow-up
5 years
Authors
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Adds minimal prognostic value beyond traditional factors; hypothesis-generating and should not yet change practice.
Cohort (n=2,792)
Yes
Does brachial flow-mediated dilation predict incident cardiovascular events in older adults?
Effect estimate: HR 0.91 (95% CI 0.83 to 0.99)
Absolute Event Rate: 78.3% vs 73.6%
p-value: p=0.02
While brachial flow-mediated dilation predicts future cardiovascular events in older adults, it adds minimal prognostic value beyond traditional cardiovascular risk factors.
Yeboah et al. (2007) conducted a cohort in Incident cardiovascular events (n=2,792). Brachial flow-mediated dilation (FMD) vs. FMD less than or equal to sex-specific medians was evaluated on Incident cardiovascular events (HR 0.91, 95% CI 0.83 to 0.99, p=0.02). Brachial flow-mediated dilation predicted incident cardiovascular events (HR 0.91 per SD; 95% CI 0.83-0.99; P=0.02) but added only ~1% to the prognostic accuracy of traditional risk factors.
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