Key result
Coronary sinus PTX3 is linked to ~133% higher coronary stenosis prevalence in chronic stable angina.
Why the study?
The diagnostic value of systemic arterial and coronary sinus PTX3 for estimating pretest probability of CAD in intermediate-risk chronic stable angina patients was unclear.
Does systemic arterial PTX3 concentration predict angiographically-determined coronary artery stenosis in patients with intermediate-risk chronic stable angina?
Population
100 patients with DTS-determined intermediate-risk chronic stable angina without previous CAD
Comparison
Systemic arterial (femoral artery) and coronary sinus PTX3 concentrations
Design
Cross-sectional analysis at a referral cardiology hospital
Authors
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PTX3 may aid stenosis risk stratification in stable angina; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=100)
Does systemic arterial PTX3 concentration predict angiographically-determined coronary artery stenosis in patients with intermediate-risk chronic stable angina?
Relative Risk: 2.33 (95% CI 1.64–3.31)
Systemic arterial PTX3 levels independently predict angiographic coronary stenosis and improve risk reclassification in patients with intermediate-risk chronic stable angina.
Eisalo et al. (1965) conducted a cross-sectional in chronic stable angina (n=100). Coronary sinus and femoral artery PTX3 concentrations was evaluated on Prevalence rate of angiographically-determined coronary artery stenosis (PRR 2.33, 95% CI 1.64-3.31). Coronary sinus (PRR 2.33; 95% CI 1.64-3.31) and femoral artery PTX3 (PRR 2.09; 95% CI 1.46-2.97) independently predicted the prevalence of coronary artery stenosis in chronic stable angina.
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