What question did this study set out to answer?

To determine whether gastric enterochromaffin-like (ECL) cell carcinoids in rats result from prolonged hypergastrinemia or are caused by specific properties of long-acting acid-inhibiting drugs.

February 3, 2009Digestion

Gastrin and Gastric Enterochromaffin-like Cell Carcinoids in the Rat

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Authors

ECEnar CarlssonUniversity of Liverpool NHNiilo HavuSödertälje Sjukhus HMH. MattssonAstraZeneca (Sweden)

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Implication

Preclinical study demonstrates that sustained hypergastrinemia induces gastric ECL cell carcinoids in rats, indicating a hormonal rather than drug-specific carcinogenic mechanism.

Key Points

To determine whether gastric enterochromaffin-like (ECL) cell carcinoids in rats result from prolonged hypergastrinemia or are caused by specific properties of long-acting acid-inhibiting drugs.
Induced hypergastrinemia non-pharmacologically in rats using 4 weeks of exogenous gastrin infusion (4 μg/kg/h) or partial gastric corpectomy evaluated at 10 weeks.
Administered omeprazole (14 mg/kg/day) for 1 year to test reversibility upon gastrin normalization, and dietary ranitidine (2 g/kg/day) for 2 years in female rats (N=100) using Grimelius and Sevier-Munger silver staining.
Exogenous gastrin increased ECL cell density from 180 to 250 cells/field, and corpectomy elevated plasma gastrin from 200 to 800 pg/ml with ECL density rising from 190 to 310 cells/field; omeprazole-induced hyperplasia reversed completely after gastrin normalization.
Life-long dietary ranitidine (2 g/kg/day for 2 years) produced sustained hypergastrinemia and induced gastric ECL cell carcinoids in 19 out of 100 rats.

Cite This Study

Carlsson et al. (2009) studied this question.

synapsesocial.com/papers/6ab0e69ce30461dadc64bdc9 https://doi.org/10.1159/000200510

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Implication

Preclinical study demonstrates that sustained hypergastrinemia induces gastric ECL cell carcinoids in rats, indicating a hormonal rather than drug-specific carcinogenic mechanism.

Gastrin and Gastric Enterochromaffin-like Cell Carcinoids in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Gastrin and Gastric Enterochromaffin-like Cell Carcinoids in the Rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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