Key result
Cycling-induced arterial noradrenaline increases closely correlate with heart rate, a pattern missed by venous sampling.
Why the study?
The arterial and venous plasma catecholamine responses during submaximal steady-state exercise and their relationship with cardiovascular variables were not fully characterized.
How do arterial and venous plasma catecholamines respond to submaximal steady-state exercise in young men?
How do arterial and venous plasma catecholamines respond to submaximal steady-state exercise in young men?
Arterial plasma catecholamines respond to steady-state exercise in a two-phase pattern that parallels changes in arterial blood pressure and heart rate, an association not revealed by venous sampling.
Answers are grounded in this paper and cite their sources.
Arterial noradrenaline sampling may better track sympathetic activation during exercise than venous; leaves open standardization in clinical physiology protocols.
Arterial and venous plasma catecholamine responses to 15 min of cycling at 60% of maximal oxygen uptake were examined 11 times during exercise and recovery in nine young men. Intra-arterial blood pressure, heart rate and oxygen uptake were recorded continuously. All variables increased significantly during the initial 4 min, after which oxygen uptake, diastolic blood pressure and arterial plasma adrenaline showed no further increase. Heart rate and plasma noradrenaline, however, continued to increase, although significantly more slowly, and were closely correlated (r = 0.81, 95% CI 0.71-0.87), as were systolic blood pressure and heart rate (r = 0.78, 95% CI 0.71-0.87). Venous plasma adrenaline showed a steady increase during the whole exercise period and thus a different response pattern from arterial plasma adrenaline. In conclusion, arterial plasma catecholamines respond to steady-state exercise by a two-phase pattern paralleling the changes in arterial blood pressure and heart rate. Venous sampling does not reveal this association.
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Rostrup et al. (1998) studied this question. Cycling exercise was evaluated on Correlation between heart rate and arterial plasma noradrenaline during exercise (r = 0.81, 95% CI 0.71-0.87). 15 minutes of cycling induced arterial plasma noradrenaline increases that closely correlated with heart rate (r=0.81; 95% CI 0.71-0.87), a pattern not revealed by venous sampling.
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