Key result
RSV-associated seizures link to elevated CSF IL-6 and viral presence, suggesting direct neurological invasion.
Why the study?
Neurological involvement in children with respiratory syncytial virus infection-associated seizures and its cerebrospinal fluid abnormalities were not well characterized.
Neurological involvement in RSV-associated seizures may be caused by direct viral invasion of the central nervous system.
May warrant caution in attributing RSV seizures solely to fever; case report leaves direct CNS invasion hypothesis-generating pending larger studies.
We report 3 cases of respiratory syncytial virus infection-associated seizures; their abnormalities of cerebrospinal fluid (increased interleukin-6 and positive for virus by highly sensitive assay) were documented. These data revealed that neurological involvement might be caused by a direct invasion.
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Kawashima et al. (2009) studied this question. Children with respiratory syncytial virus-associated seizures showed cerebrospinal fluid abnormalities (increased interleukin-6 and viral presence), suggesting direct neurological invasion.
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