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July 22, 2026iScienceOpen Access

NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a Drosophila tauopathy model

Francesco Paonessa Bernardo Delarue Bizzini Tom Campbell Emily Coode Jonathan Lam Ravi Solanki Richard Butler J. L. Smith Catherine M. Davidson Delphine Larrieu Andrea H. Brand Rick Livesey

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Abstract

-mutant neurons. We conclude that NAT10 mediates neuronal pathologies in tauopathies and is a potential therapeutic target in these diseases.

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Paonessa et al. (2026) studied this question.

synapsesocial.com/papers/6ab0e98a7eace3eb087ff0ca https://doi.org/10.1016/j.isci.2026.116861

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Neurodegenerative Disease TauopathiesReview · 2023 · 140 citations
2Tau and neurodegenerationOriginal Research · 2023 · 66 citations
3Invited review: Frontotemporal dementia caused by <i>microtubule‐associated protein tau</i> gene (<scp><i>MAPT</i></scp>) mutations: a chameleon for neuropathology and neuroimagingReview · 2014 · 439 citations
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5Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndromeOriginal Research · 2018 · 209 citations

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