Comparative effectiveness of diosmin and hesperidin combination in patients with chronic venous insufficiency

Objective. Comparative analysis of the therapeutic efficacy of the combined preparation of diosmin and hesperidin in two cohorts of patients with chronic venous insufficiency (CVI) stratified by body mass index. Material and methods. A prospective clinically controlled study of the efficacy of therapy with the combination of diosmin and hesperidin in 104 patients with chronic venous diseases (C0-C3 according to CEAR) was carried out. The efficacy of pharmacotherapy was assessed by comparative analysis between the group of patients with excessive body weight and the group with normal anthropometric indices. Results. After 8 weeks of treatment with the combination of diosmin and hesperidin a significant decrease in the severity of discomfort in the lower extremities, intensity of heaviness, leg pain and the feeling of leg oedema was observed . The effect of the therapy in both groups was a decrease in the volume of the lower leg and improvement of the CIVIQ-20 quality of life scores (p < 0.01). Conclusion. The obtained data indicate comparable high efficacy of the combination of diosmin and hesperidin for treatment of clinical manifestations of CVI in patients with both normal and overweight.