Introduction and synthesis of polymeric prodrugs

The conventional drug delivery system with small molecular weight usually exhibits shorter half-life, non-specific target in the blood stream and higher overall clearance rate.Thus, higher doses are often required for therapy purposes and may cause terrible sides effects like toxicities on the body.Due to the organ toxicities caused by these unfavorable physical and chemical properties, new drug delivery systems such as polymeric with higher bioavailability and less side effects are in highly demand.In this mini review, we aid at bringing up an overview of polymer prodrugs with their advantages and shortages.