Key result
Lichen planus is linked to impaired left atrial strain and prolonged atrial conduction times.
Why the study?
Lichen planus is a chronic inflammatory disease associated with increased cardiovascular risk, but its relationship with atrial conduction and left atrial strain parameters is unclear.
Are left atrial strain parameters and total atrial conduction time altered in patients with lichen planus compared to healthy controls?
Case-Control (n=80)
Are left atrial strain parameters and total atrial conduction time altered in patients with lichen planus compared to healthy controls?
Patients with lichen planus exhibit subclinical cardiac involvement characterized by impaired left atrial myocardial deformation and prolonged total atrial conduction time.
Answers are grounded in this paper and cite their sources.
May indicate subclinical atrial involvement in lichen planus; leaves open prognostic value and need for prospective validation.
Background Lichen planus (LP) carries the increased risk of cardiovascular events as it is a chronic inflammatory disease. This study aimed at determining the relationship between total atrial conduction time (TACT), P-wave dispersion, and the left atrium (LA) global strain in the patients with LP. Methods Forty people as a control group and 40 patients with LP were included in this study. Patient assessed global longitudinal LA strain by two-dimensional speckle-tracking strain echocardiography. Results The global peak systolic LA myocardium strain during the left ventricular systole (LAGLSRs) and the global peak negative LA myocardial strain rate during the early ventricular diastole (LAGLSRe) values were significantly lower in the patients with LP in proportion to the control group according to the strain measurements (1.7 ± 0.07 vs. 1.9 ± 0.1%, p = 0.001; 1.23 ± 0.04 vs. 1.2 ± 0.08 s−1, p = 0.001), respectively. TACT value was found to be significantly longer (102.6 ± 6.3 ms) in the patients with LP than the control group (96.3 ± 5.3 ms, p = 0.001), considering the terms of the artial conduction features. Conclusion This study demonstrated that the subclinical cardiac involvement in LP can determine the prolonged TACT and the impaired left atrial myocardial deformation values.
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Duman et al. (2018) conducted a case-control in Lichen planus (n=80). Lichen planus vs. Control group was evaluated on Global peak systolic LA myocardium strain during left ventricular systole (LAGLSRs) (p=0.001). Patients with lichen planus had significantly lower global peak systolic left atrial myocardium strain (1.7% vs 1.9%, p=0.001) and longer total atrial conduction time compared to controls.
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