Key result
Oral hypoglycemic agents offer safe alternatives to insulin for gestational diabetes without increasing congenital anomalies.
Why the study?
Oral hypoglycemic agents could be effective and safe alternatives to insulin therapy for gestational diabetes, but their use complicates clinical decision-making.
Do oral hypoglycemic agents provide an effective and safe alternative to insulin therapy in pregnant women with gestational diabetes?
Do oral hypoglycemic agents provide an effective and safe alternative to insulin therapy in pregnant women with gestational diabetes?
Oral hypoglycemic agents may offer an effective and safe alternative to insulin therapy for the management of gestational diabetes.
May support oral agents as insulin alternatives in gestational diabetes; leaves open need for randomized confirmation of safety.
Oral agents are the mainstay of pharmacological treatment for non-pregnant women with type 2 diabetes. It has been proposed that, owing to the similarity between gestational and type 2 diabetes, some of these drugs could be used effectively and safely as alternatives to insulin therapy. This efficacious alternative provides the physician with more choices that, in turn, translate into more complex decision-making for the management of gestational diabetes. This article illustrates the pharmacological characteristics of oral hypoglycemic agents and placental transfer, provides evidence for the lack of association between congenital anomalies and the drugs, and reviews current studies and the clinical outcomes when these drugs are used.
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Oded Langer (2002) conducted a review in Gestational diabetes. Oral hypoglycemic agents vs. Insulin therapy was evaluated. Oral hypoglycemic agents are reviewed as effective and safe alternatives to insulin therapy for gestational diabetes, with evidence showing no association with congenital anomalies.
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