Key result
Cell-associated attenuated ILT vaccine elicits stronger immunity and antibody responses versus cell-free vaccine in chickens.
Why the study?
The immune response and in vivo distribution of ILT virus after inoculation with cell-associated versus cell-free vaccines in chickens were not fully characterized.
Supports cell-associated ILT vaccines in poultry; hypothesis-generating pending field trials.
Chickens inoculated with the cell-associated (CA) vaccine acquired higher protective immunity to ILT. In chickens vaccinated with CA or cell-free (CF) vaccine, respectively, virus-neutralizing and IgG- and IgM-ELISA antibodies were detected in the serum, but no antibody was detected in the tracheal washes of the vaccinated chickens. More apparent antibody response was seen in chickens vaccinated with the CA vaccine than with the CF vaccine. The antibody titers did not correlate closely with the protection against challenge with ILT virus. After subcutaneous injection of either CA or CF vaccine, ILT virus was isolated from the liver, spleen, thymus, lungs and other organs of the chickens from 1 to 6 days after injection, and there was no correlation of the isolation rate for the CA-vaccinated and the CF-vaccinated chickens.
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Honda et al. (1994) studied Infectious Laryngotracheitis (ILT). Cell-associated (CA) vaccine of attenuated ILT virus vs. Cell-free (CF) vaccine was evaluated on Protective immunity and antibody response. Cell-associated vaccine of attenuated ILT virus elicited higher protective immunity and more apparent antibody responses in chickens compared to the cell-free vaccine.
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