Key result
Generalized epileptic seizure linked to takotsubo cardiomyopathy, suggesting temporal lobe hyperactivity triggers autonomic dysfunction.
Why the study?
The relationship between epilepsy-related temporal lobe hyperactivity and takotsubo cardiomyopathy is not well understood.
Case Report (n=1)
No
This case suggests a potential link between temporal lobe hyperactivity during seizures and the development of takotsubo cardiomyopathy via autonomic nervous system dysfunction.
Should not alter practice after one case; leaves open autonomic link between temporal hyperperfusion and takotsubo cardiomyopathy.
A 60-year-old woman with a history of symptomatic seizures secondary to a subarachnoid hemorrhage was admitted to hospital because of a generalized seizure. The following day, her electrocardiogram showed negative T waves in II, III, (a)V(F), and V(2-6), and the echocardiogram showed an impaired left ventricular ejection fraction with ventricular apical akinesia. Head magnetic resonance imaging showed no acute brain injury, but single photon emission computed tomography (SPECT) showed hyperperfusion which affected the left temporal cortex in particular. Hyperactivity of the temporal lobe might cause autonomic nervous system dysfunction and might be related to takotsubo cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
Naganuma et al. (2011) conducted a case report in Epilepsy and Takotsubo Cardiomyopathy (n=1). Generalized epileptic seizure was evaluated on Clinical and imaging findings of takotsubo cardiomyopathy. A generalized epileptic seizure preceded takotsubo cardiomyopathy, with SPECT showing left temporal cortex hyperperfusion, suggesting temporal lobe hyperactivity may cause autonomic dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: