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November 3, 2021Open Access

En Bloc Resection of Right Renal Cell Carcinoma and Inferior Vena Cava with Tumor Thrombus: Is It Safe to Divide the Left Renal Vein?

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Key result

Right RCC and IVC resection without reconstruction is not linked to long-term renal function decline.

  • n=22

Why the study?

There are no reports evaluating mid- and long-term effect on renal function after resection of right renal cell carcinoma and IVC with tumor thrombus without IVC reconstruction.

Does resection of right renal cell carcinoma and inferior vena cava without reconstruction affect long-term renal function in patients with obstructing level II-IV tumor thrombus?

Comparison

Resection without reconstruction of the inferior vena cava

Design

Bi-institutional retrospective review

Follow-up

12 months

Authors

LHLaura HorodyskiUniversity of MiamiJGJavier García GonzálezHospital General Universitario Gregorio MarañónMTMarina M. TabbaraUniversity of Miami

Discussion

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Member takes

Implication

May support IVC resection without reconstruction in select right RCC cases with collaterals; leaves open mid- and long-term renal outcomes.

Study Design

Type

Observational (n=22)

Multicenter

Yes

Structured PICO

Does resection of right renal cell carcinoma and inferior vena cava without reconstruction affect long-term renal function in patients with obstructing level II-IV tumor thrombus?

P
Population
22 patients (median age 62.5 years, 14% female) with right renal cell carcinoma and obstructing level II-IV tumor thrombus undergoing en bloc resection without IVC reconstruction, followed for up to 12 months.
E
Exposure
Resection of right renal cell carcinoma and inferior vena cava without reconstruction of the inferior vena cava
O
Outcome
Long-term renal function (creatinine levels at 6 and 12 months)surrogate

Resection of right renal cell carcinoma with IVC tumor thrombus without IVC reconstruction does not appear to significantly impair long-term renal function.

Limitations

  • Small sample size due to rarity of cases
  • Retrospective design
  • Missing follow-up creatinine data for some patients
  • Outcomes may not be reproducible by surgical teams of different volume and experience
  • Eight patients lost to follow-up
  • Two died

Cite This Study

Horodyski et al. (2021) conducted an observational in Right renal cell carcinoma with obstructing level II-IV tumor thrombus (n=22). Right radical nephrectomy with en bloc resection of the IVC and tumor thrombus without caval reconstruction was evaluated on Long-term renal function (post-operative creatinine). En bloc resection of right renal cell carcinoma and inferior vena cava without caval reconstruction did not adversely impact long-term renal function, with median creatinine at 12 months being 1.34 mg/dL.

synapsesocial.com/papers/6ab1d2d40bc4acb8a01dce01https://doi.org/10.21203/rs.3.rs-1018090/v1
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes in Patients with Renal Cell Carcinoma Undergoing Inferior Vena Cava Ligation without Reconstruction versus Thrombectomy: A Retrospective, Case Controlled Study2020 · 18 citations
  2. 2Surgical Treatment of Renal Cancer with Vena Cava Extension1987 · 554 citations
  3. 3Left Renal Vein Reconstruction After Right Nephrectomy and Inadvertent Left Renal Vein Ligation: A Case Report and Review of the Literature2006 · 9 citations