Key result
Angina with normal epicardial arteries is linked to impaired GLS compared to healthy controls.
Why the study?
Global longitudinal strain assessed by 2D speckle tracking echocardiography may provide a non-invasive method to detect subclinical LV systolic dysfunction in patients with angina and normal epicardial coronary arteries.
Does GLS assessed by 2D-STE detect subclinical LV systolic dysfunction in patients with angina and normal epicardial coronary arteries compared to healthy controls?
Population
120 participants (60 angina patients with normal coronaries, 60 healthy controls)
Comparison
Patients with angina and normal coronaries vs healthy controls
Design
Comparative case–control study
Authors
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May support GLS for subclinical LV dysfunction in angina with normal coronaries; hypothesis-generating and should not yet change practice.
Case-Control (n=120)
Does GLS assessed by 2D-STE detect subclinical LV systolic dysfunction in patients with angina and normal epicardial coronary arteries compared to healthy controls?
Absolute Event Rate: -18.78% vs -19.7%
p-value: p=<0.007
GLS assessed by 2D-STE can detect subclinical LV systolic dysfunction in patients with angina and normal coronary arteries, suggesting its utility in identifying underlying microvascular disease despite preserved LVEF.
Hoque et al. (2023) conducted a case-control in Angina with normal epicardial coronary arteries (n=120). Angina with normal epicardial coronary arteries vs. Healthy individuals was evaluated on Global longitudinal strain (GLS) (p=<0.007). Patients with angina and normal epicardial coronary arteries had significantly impaired global longitudinal strain compared to healthy controls (-18.78% vs -19.7%; p<0.007).
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