Indium-mediated diastereoselective allylation reactions: preparation of α-hydroxy and α-amino acids

The hemiacetals of (+)- and (−)-N-glyoxyloylbornane-10,2-sultam and their imines reacted with allyl iodide in the presence of indium in DMF to give the corresponding α-hydroxy and α-amino camphor sultam derivatives with high diastereoselectivities (86–90% de). This method could be useful for preparation of α-hydroxy and α-amino acids.