Key result
PGF2 alpha potentiates serotonin-induced vasoconstriction, boosting chorionic vein contractile response by ~116%.
Why the study?
The effects of serotonin and its interaction with prostaglandin F2 alpha on vascular tension and perfusion pressure in human placental chorionic veins were not fully understood.
Serotonin and PGF2 alpha interact to strongly induce vasoconstriction in human placental chorionic veins, likely playing a role in regulating placental blood flow.
May inform placental vasoregulation mechanisms; leaves open translation to human pregnancy outcomes.
In vitro experiments using isolated rings and perfused segments of human chorionic veins, were designed to determine the effects of serotonin and their interaction with PGF2 alpha on vascular tension and perfusion pressure. These vessels responded vigorously with high sensitivity to the vasoconstrictor effects of serotonin in both experimental designs. Administration of PGF2 alpha also led to constriction of the veins, but this autacoid is at least 100 times less potent than serotonin. When adding PGF2 alpha previously to serotonin to the bathing fluid or to the perfusate, the serotonin response was significantly potentiated, increasing the maximal contractile response in 116 +/- 12% and the perfusion pressure in 180 +/- 25%. Both autacoids probably operate in this vascular bed interacting with each other and playing an important role in the regulation of placental blood flow in vivo.
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lez et al. (2010) studied this question. Serotonin and PGF2 alpha vs. Serotonin alone was evaluated on Maximal contractile response and perfusion pressure. Pre-treatment with PGF2 alpha significantly potentiated serotonin-induced vasoconstriction in human chorionic veins, increasing maximal contractile response by 116% and perfusion pressure by 180%.
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