Key result
SSRI use linked to ~330% higher odds of low postprandial SBP, a fall risk factor.
Why the study?
The association between postprandial blood pressure, falls, and medications in older people is controversial and requires investigation.
Population
179 semi-independent older people (mean age 83.2 +/- 7.0 years) in residential care facilities
Comparison
Postprandial blood pressure responses with and without medication use and history of falls
Design
Cross-sectional observational study
Authors
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SSRIs and antipsychotics may raise postprandial hypotension risk in residential care residents; leaves open causal confirmation via prospective studies.
Cross-Sectional (n=179)
Yes
Odds Ratio: 4.3 (95% CI 1.4–13.1)
p-value: p=0.006
In older people in residential care, postprandial hypotension is common and associated with falls, with SSRIs and antipsychotics identified as significant risk factors.
Couteur et al. (2003) conducted a cross-sectional in Postprandial hypotension and falls (n=179). Selective serotonin reuptake inhibitors vs. Non-use was evaluated on Low postprandial systolic blood pressure (≤115 mm Hg) (OR 4.3, 95% CI 1.4-13.1, p=0.006). Use of selective serotonin reuptake inhibitors was significantly associated with low postprandial systolic blood pressure (OR 4.3; 95% CI 1.4-13.1; p=0.006), a risk factor for falls in older adults.
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