Key result
Postmenopausal type 2 diabetics with knee osteoarthritis have higher HbA1c and fasting glucose vs healthy controls.
Why the study?
Type 2 diabetes is a frequent comorbidity in elderly female patients with knee osteoarthritis, but the role of blood biochemical parameters in this population is not well defined.
Case-Control (n=110)
No
p-value: p=<0.001
Postmenopausal women with type 2 diabetes and knee osteoarthritis exhibit significantly elevated glycemic and atherogenic lipid parameters compared to healthy controls.
Higher HbA1c and FBS were linked to knee OA in diabetic postmenopausal women; leaves open whether glycemic optimization alters OA risk or progression.
Background: Knee osteoarthritis is the most common form of joint disorder and a leading cause of pain and functional disability among elderly female population. Type 2-diabetes is frequently reported comorbidity in elderly female patients with knee osteoarthritis. Therefore, the aim of this study is to assess the role of various blood biochemical parameters in cases of knee osteoarthritis among type 2 diabetic postmenopausal women. Methods: The present study conducted in the Department of Orthopaedics, Pacific Medical College and Hospital, Udaipur, Rajasthan. 55 type 2-diabetic female subjects of age above 50 years were enrolled as cases and 55 normal healthy female age matched individuals as controls. Osteoarthritis of knee was ascertained using the American college of rheumatology classification criteria. Results: The mean levels of fasting blood sugar, HbA1c, total cholesterol, TG, LDL-C and VLDL-C were also found significantly increased while HDL-C was found significantly decreased in cases as compared to controls. Conclusions: We concluded that there is a positive correlation with increased levels of HbA1c and FBS (p˂0.001) in diabetic postmenopausal women and knee osteoarthritis.
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Rajat Malot (2017) conducted a case-control in Knee osteoarthritis and Type 2 diabetes (n=110). Type 2 diabetes with knee osteoarthritis vs. Normal healthy age-matched females was evaluated on Blood biochemical parameters including HbA1c and fasting blood sugar (p=<0.001). Type 2 diabetic postmenopausal women with knee osteoarthritis had significantly higher levels of HbA1c and fasting blood sugar compared to healthy controls (P<0.001).
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