In vitro study reveals potent alpha-mannosidase inhibition by self-assembled glycopolypeptide micelles, suggesting new opportunities for bioactive drug delivery.
Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.
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Bonduelle et al. (2014) studied this question.
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