Profiling of exosomal microRNAs expression in umbilical cord blood from normal and preeclampsia patients

Fig. 1. Characteristics of human serum exosomes. A Western blot analysis of exosomes surface markers (CD63). B Representative nanoparticle tracking analysis (NTA) profile human serum exosomes C Serum-derived exosomes as observed under electron microscope (scale bar, 200 nm)

Fig. 2. Cluster analysis of differentially expressed exosomal miRNAs isolated from serum of PE patients and normal controls. A Heat map showing hierarchical clustering (HCL) of normalized levels of the 157 differentially expressed microRNAs from PE (n = 5) and normal control (n = 5). B Volcano map showing distribution of differentially expressed microRNAs based on the p values and fold-changes. p < 0.05 and |log 2(fold-change) | ≥1 were used to show differential expression

Fig. 3. Gene ontology (GO) enrichment analysis of predicted target genes. A GO analysis of differentially expressed genes for Biological Process (BP), Molecular Function (MF), and Cellular Component (CC) terms

Fig. 4. KEGG pathway analysis for predicted target genes of differentially expressed miRNAs. A Coordinate axis X: -log10 (P-value); coordinate axis Y: Pathway-Term entry name. B Coordinate axis X: -log10 (P-Value); coordinate axis Y: Pathway-Term entry name