What question did this study set out to answer?

To examine the structural organization and functional role of descending prefrontal cortex projections to the dorsal raphe nucleus in regulating social approach-avoidance decisions following social defeat.

January 1, 2014Frontiers in Behavioral NeuroscienceOpen Access

Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat

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To examine the structural organization and functional role of descending prefrontal cortex projections to the dorsal raphe nucleus in regulating social approach-avoidance decisions following social defeat.
Mapped ventromedial prefrontal cortex (vmPFC) glutamatergic projections to dorsal raphe nucleus (DRN) serotonin and GABAergic subregions using viral tracing and Cre-dependent genetic labeling.
Assessed functional connectivity and immediate early gene induction in DRN neurons using slice electrophysiology and cFos mapping.
Bidirectionally manipulated vmPFC inputs to the DRN using optogenetics during aggressor cue exposure in a social defeat model.
Excitatory vmPFC axon terminals localized predominantly to GABA-rich regions of the DRN and directly engaged GABAergic neurons via an AMPA receptor-dependent mechanism.
vmPFC stimulation induced robust cFos expression in DRN GABA neurons, while synaptic excitation and cFos induction in serotonin neurons were minimal.
Optogenetic stimulation of vmPFC inputs to the DRN enhanced social avoidance bias, whereas optogenetic inhibition diminished avoidance during sensory exposure to aggressor cues.

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Implication

Preclinical study reveals prefrontal inputs to dorsal raphe GABA neurons bidirectionally control social avoidance after social defeat, highlighting inhibitory gating of serotonin output.

Cite This Study

Challis et al. (2014) studied this question.

synapsesocial.com/papers/6ab1ddb18addc494cf73da1c https://doi.org/10.3389/fnbeh.2014.00043

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Implication

Preclinical study reveals prefrontal inputs to dorsal raphe GABA neurons bidirectionally control social avoidance after social defeat, highlighting inhibitory gating of serotonin output.

Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat

Key Points

Discussion

Implication

Cite This Study

Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socioaffective choices after social defeat

Key Points

Discussion

Implication

Cite This Study

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