Key result
CSVD is not linked to higher resistive index of the internal and common carotid arteries.
Why the study?
Cerebroarterial pulsatility measured by resistive index in internal and common carotid arteries in patients with cerebral small vessel disease has not been well characterized.
Does the resistive index of the internal and common carotid arteries differ in patients with cerebral small vessel disease compared to those without?
Observational (n=79)
Does the resistive index of the internal and common carotid arteries differ in patients with cerebral small vessel disease compared to those without?
In a small retrospective cohort, the resistive index of the internal and common carotid arteries was not significantly higher in patients with cerebral small vessel disease compared to those without.
No association of CSVD with higher carotid RI; leaves open its value as a microvascular marker in larger prospective studies.
Background/Objective: Cerebroarterial pulsatility has been reported to be significantly increased in patients with cerebral small vessel disease (CSVD). Resistive index (RI) is a parameter of pulsatility and describes resistance of the vascular wall. This study aims to describe RI of internal carotid artery (ICA) and common carotid artery (CCA) in CSVD. Methods: This retrospective study evaluated the registry in Neurosonology Lab, between January and June of 2020. Patients were categorized into CSVD and non CSVD diagnosed using brain scan or MRI. CSVD markers such as lacune, microbleeds, perivascular space, and fazekas class are evaluated from MRI. RI of ICA and CCA were measured using Carotid Doppler Ultrasound. Uni- and bivariate analysis were done to evaluate the mean difference. Result: There were 79 subjects with a median age of 60 (49–66) years, comprising 54.4% with CSVD. RI in CSVD was not significantly higher than non CSVD and tended to be lower. RI of patients with CSVD markers such as lacune (ICA 0.69 ± 0.9, CCA 0.77 ± 0.08), microbleeds (ICA 0.68 ± 0.06, CCA 0.72 ± 0.08), perivascular space > 11 (ICA 0.80 ± 0.17, CCA 0.77 ± 0.05) and fazekas ≥2 (ICA 0.69 (0.09), CCA 0.76 (0.08)) tended to be higher than normal population. Conclusions: This study did not find a significantly higher RI in CSVD compared to non-CSVD, but RI of ICA and CCA in CSVD patient has a tendency to be higher than normal population. Further studies with larger sample sizes are needed to determine role of RI.
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Rinjani et al. (2021) conducted an observational in Cerebral small vessel disease (CSVD) (n=79). Cerebral small vessel disease (CSVD) vs. Non-CSVD was evaluated on Resistive index (RI) of internal carotid artery (ICA) and common carotid artery (CCA). Cerebral small vessel disease was not associated with a significantly higher resistive index of the internal and common carotid arteries compared to non-CSVD.
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