Key result
PRECiSe low prime volume system linked to ~71% lower transfusion need vs standard heart-lung machines.
Why the study?
Standard heart-lung machines cause substantial hemodilution leading to impaired organ function and increased blood transfusions in coronary artery bypass surgery.
Does the PRECiSe low prime volume system reduce perioperative myocardial damage, hemodilution, and transfusions in patients undergoing coronary artery bypass surgery?
Observational (n=80)
Does the PRECiSe low prime volume system reduce perioperative myocardial damage, hemodilution, and transfusions in patients undergoing coronary artery bypass surgery?
Absolute Event Rate: 10% vs 35%
The PRECiSe low prime volume system significantly reduces hemodilution and the need for blood transfusions during coronary artery bypass surgery compared to standard heart-lung machines.
May support low-prime systems to limit transfusions in CABG; hypothesis-generating and requires randomized confirmation.
Standard heart-lung machines lead to substantial hemodilution with associated impaired organ function and increased need for blood transfusions. The aim of this study was to evaluate the effect of the new PRECiSe low prime volume system on perioperative myocardial damage, hemodilution, and transfusions. In a case-matched prospective study, 40 patients undergoing coronary artery bypass surgery using PRECiSe were compared with 40 patients on a standard heart-lung machine. In the PRECiSe group, the prime volume was significantly reduced, resulting in less hemodilution and transfusion requirements during and after extracorporeal circulation: only 10% of patients needed transfusions vs. 35% in the control group, with an average transfusion need of 0.16 vs. 1.25 units. There were no significant differences in perioperative cardiac-specific enzymes. The PRECiSe system was considered safe and effective for coronary artery bypass surgery.
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Beholz et al. (2006) conducted an observational in Coronary artery bypass surgery (n=80). PRECiSe low prime volume system vs. Standard heart-lung machine was evaluated on Need for transfusions. The PRECiSe low prime volume system reduced the need for transfusions compared to a standard heart-lung machine (10% vs. 35%) in patients undergoing coronary artery bypass surgery.
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