Key result
Probiotic and vitamin D co-supplementation improves some migraine characteristics but fails to reduce headache duration.
Why the study?
Routine medications for migraine treatment are not effective for all patients and may have side effects, prompting investigation of alternative therapies such as vitamin D and probiotic co-supplementation.
Does probiotic and vitamin D co-supplementation improve clinical symptoms, mental health, and inflammation in adult patients with migraine headache?
RCT
Triple-blinded
Randomized
Does probiotic and vitamin D co-supplementation improve clinical symptoms, mental health, and inflammation in adult patients with migraine headache?
p-value: p=0.017
Probiotic and vitamin D co-supplementation for 12 weeks may have beneficial effects on some migraine headache characteristics, though it does not significantly improve headache duration, mental health scores, or inflammation.
Supports adjunctive vitamin D-probiotic for reducing migraine frequency and severity; extends nutritional intervention evidence but requires replication.
BACKGROUND: Migraine headache is a major public health problem. Routine medications for migraine treatment are not useful in treating all patients and may have some side effects. The present study aimed to investigate the effect of vitamin D and probiotic co-supplementation on clinical characteristics of migraine, daily functioning, mental health outcomes, and serum levels of high-sensitivity C-reactive protein (hs-CRP). METHODS: CFU per day) or placebo for 12 weeks. The Headache Impact Test (HIT-6) and Depression, Anxiety, and Stress Scale (DASS) questionnaires were administered to patients at baseline and after 12 weeks. In addition, the frequency, duration, and severity of migraine headaches per month were assessed using a self-administered 30-day headache diary at baseline and the end of the intervention. Anthropometric indices, blood pressure, and serum levels of 25-hydroxy vitamin D and hs-CRP were also examined at first and the end of the study. RESULTS: 0.29; P = 0.017) in the probiotic and vitamin D group than the placebo group. No significant difference was found between the two arms of the intervention regarding the change in headache duration, hs-CRP, scores of DASS, and HIT-6 questionnaires (P > 0.05). CONCLUSIONS: This trial showed that probiotic and vitamin D co-supplementation for 12 weeks has beneficial effects on migraine headache characteristics. Further research is needed to confirm this finding.
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Tirani et al. (2024) conducted an RCT in Migraine headache. Probiotic and vitamin D co-supplementation vs. Placebo was evaluated on Clinical characteristics of migraine, daily functioning, mental health outcomes, and serum levels of hs-CRP (p=0.017). Probiotic and vitamin D co-supplementation for 12 weeks improved some migraine headache characteristics (P=0.017), but did not significantly change headache duration, hs-CRP, DASS, or HIT-6 scores.
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